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LOS ANGELES, CA - JANUARY 09: The cast of "Grey's Anatomy" accepts the award for Favorite TV Drama onstage during the 33rd Annual People's Choice Awards held at the Shrine Auditorium on January 9, 2007 in Los Angeles, California. (Photo by Kevin Winter/Getty Images)

Whoa!  THIS IS A SHOCKER!  Justin Chambers, better known as Alex Karev is leaving Grey’s!

ABC confirmed to PEOPLE that the 49-year-old original cast member has left the beloved medical drama after starring as Dr. Alex Karev for 16 seasons. His final episode aired on Nov. 14, 2019.

“There’s no good time to say goodbye to a show and character that’s defined so much of my life for the past 15 years,” Chambers said in a statement to Deadline. “For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time.”

He added, “As I move on from Grey’s Anatomy, I want to thank the ABC family, Shonda Rimes, original cast members Ellen Pompeo, Chandra Wilson and James Pickens, and the rest of the amazing cast and crew, both past and present, and, of course, the fans for an extraordinary ride.”